Solitary Fibrous Tumor of the Conjunctiva with Heretofore Undescribed Pathologic Findings
Korean Journal of Pathology
;
: 315-318, 2011.
Article
in English
| WPRIM
| ID: wpr-47957
ABSTRACT
A 37-year-old female presented with a conjunctival mass discovered 3 years prior. An excisional biopsy revealed a patternless proliferation of round and spindle-shaped cells with an eosinophilic fibrillary cytoplasm and vesicular nuclei with occasional inclusions. Psammoma bodies were arranged around the dilated irregularly-shaped vessels. Differential diagnoses included conjunctival solitary fibrous tumor (SFT), nevus, glomangioma, ectopic meningioma, and mesectodermal leiomyoma. The tumor cells were immunoreactive for CD34, CD99, bcl-2 and vimentin, and were negative for smooth muscle actin, desmin, glial fibrillary acidic protein, S-100 protein, epithelial membrane antigen, and human melanoma black-45. Ultrastructurally, the tumor cells had rough endoplasmic reticulum, free ribosomes, and scattered mitochondria without basal lamina or cellular junctions, which are features of fibroblasts. A diagnosis of SFT was rendered based on the light microscopic, immunohistochemical, and electron microscopic findings. We report here on the second case of a SFT arising in the conjunctiva, which clinically and histologically mimics conjunctival nevus, glomangioma, ectopic meningioma, and a hybrid neurogenic-myogenic tumor such as mesectodermal leiomyoma.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Ribosomes
/
Basement Membrane
/
Vimentin
/
Biopsy
/
S100 Proteins
/
Chimera
/
Actins
/
Glomus Tumor
/
Mucin-1
/
Conjunctiva
Type of study:
Diagnostic study
Limits:
Adult
/
Female
/
Humans
Language:
English
Journal:
Korean Journal of Pathology
Year:
2011
Type:
Article
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