Clinical observation of interferon by aerosol inhalation as a part of treatment of hand -foot -and -mouth disease of children / 中国基层医药

ABSTRACT

Objective To observe the clinical efficacy of interferon by aerosol inhalation as a part of treat-ment of hand,foot and mouth disease of children.Methods The clinical data of 240 children with hand foot and mouth disease were collected,and they were divided into group A (control group)and group B (interferon treatment group)according to the order of admission.The recovery time on body temperature,rashes on the hands and feet, mouth pain,the average hospitalization time and total efficacy rate were compared.Results Group B was superior to group A in the following aspects,it took shorter time to get recovery of mouth pain,rashes on hands and feet,the aver-age hospitalization time.The recovery time for mouth pain of group A was (60.5 ±22.1 )h,which of group B was (52.8 ±19.5)h.The time for rashes on hand and foot recovery of group A was (72.3 ±25.4)h,which of group B was (54.7 ±22.5)h.The average hospitalization time of group A was (124.8 ±42.4)h,which of group was B (108.2 ±36.7)h,and the differences were statistically significant (t =2.45,2.38,2.16,P =0.018,0.015,0.032). The total effective rate of group B was 93%,which was higher than 85.3% of group A,and the difference was statistically significant (χ2 =6.012,P =0.012).Conclusion Interferon by aerosol inhalation as a part treatment of hand -foot -and -mouth disease of children (ordinary type)can increase the efficacy rate,shorten course of the disease,accelerate comprehensive rehabilitation of patients.