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A comparative study of p1 6 gene methylation status in primary tongue squamous cell carcinoma and cervical lymph node metastasis / 实用口腔医学杂志
Article in Zh | WPRIM | ID: wpr-479818
Responsible library: WPRO
ABSTRACT
DNA from 32 cases of tongue squamous cell carcinoma(TSCC)specimens and the neck lymph node metastasis specimens were processed by bisulfite treatment.The methylation of the specimens was examined by Q-MSP amplification.The consistency of p1 6 methyla-tion of primary TSCC with that of lymph node metastasis tumor was 90.62%(P <0.05).We assumed that p1 6 gene promoter CpG island methylation rates in primary TSCC and metastatic lymph nodes are consistent,p1 6 gene methylation status can be a methylation predictor be-tween premary and lymph node metstasized TSCC.
Key words
Full text: 1 Index: WPRIM Language: Zh Journal: Journal of Practical Stomatology Year: 2015 Type: Article
Full text: 1 Index: WPRIM Language: Zh Journal: Journal of Practical Stomatology Year: 2015 Type: Article