Clinical and pathological characteristics and the expression of interleukin-6, interleukin-17 and tumor necrosis factor-α in elderly patients with primary nephrotic syndrome / 中华老年医学杂志

ABSTRACT

Objective To investigate clinical and pathological characteristics and the expression of interleukin (IL)-6, IL-17 and tumor necrosis factor (TNF)-α in elderly patients with primary nephrotic syndrome.Methods A total of 75 elderly cases with primary nephrotic syndrome were chosen as the observation group, and 40 healthy elderly persons served as the control group.Fasting serum IL-6, IL-17 and TNF-α levels were measured by enzyme-linked immunosorbent assay (ELISA) for both groups.Results 67 of the 75 patients received pathological diagnoses, of whom 46 had membranous glomerulonephritis, 5 had focal segmental glomerulosclerosis, 5 had mesangiocapillary glomerulonephritis, 3 had mesangial proliferative glomerulonephritis, 3 had IgA nephropathy, and the rest included one case for each of the following disorders glomerular minor lesion, sclerosing glomerulonephritis, diffuse proliferative glomerulonephritis, segmental proliferative glomerulonephritis, and minor glomerular lesions.The expression of IL-6, IL-17 and TNF-α had statistically significant differences between the two groups.There were no statistically significant differences in the expression of IL-6 and IL-17 between patients with different pathological characteristics, and the expression of TNF-α was higher in membranous glomerulonephritis patients than in patients with other pathological characteristics.Conclusions Membranous glomerulonephritis is the main pathological type in elderly patients with primary nephrotic syndrome.Serum IL-6, IL-17 and most notably TNF-α levels are elevated in patients with membranous glomerulonephritis.