Clinical study of low molecular weight heparin combined isoproterenol inhalation in treatment of children with severe bronchial pneumonia / 国际儿科学杂志

ABSTRACT

Objective To explore clinical efficacy of low molecular weight heparin combined isoproterenol inhalation in treatment of children with severe bronchial pneumonia.Methods 110 patients from Jan 2013 to Apr 2014 were collected and randomly divided into treatment group (57 cases)and control group(53 cases), control group was given anti infection,hormone, expectorant, oxygen and other symptomatic treatment, besides, inhaled with isoprenaline, bid,based on which treatment group was inhalaled with low molecular weight heparin sodium injection, qd, arterial blood gas indexes were compared between 2 groups after 72 h treatment, and clinical efficacy were compared after 5 d treatment.Results After 72 h treatment,two groups of children with pulmonary function, arterial blood gas index and airway inflammatory improved obviously;treatment group with PaO2 and PaO2/FiO2 were significantly higher than control group, while PaCO2, CRP were significantly lower than control group, the differences of all above indexes were statistically significant (P ＜ 0.05).Treatment group with wheezing, pulmonary rales, cough disappeared time were significantly lower than control group (P ＜ 0.05).After 5d treatment,treatment group with cure rate (50.9％ vs.37.7％)and total effective rate (98.2％ vs.94.3％)were both higher than control group, the differences were not statistically significant (P ＞ 0.05) .During inhalation, two groups with incidences of temporary heart rate rise (10.5 ％ vs.13.2) had no significant difference (x2 =0.189 P =0.663).Conclusion Based on conventional treatment for children with severe pneumonia,low molecular weight heparin combined with isoproterenol inhalation can improve pulmonary ventilation function,reduce airway inflammation,and improve clinical efficacy to a certain extent.