Improved synthesis of 2,5 -anhydro-3,4,6-tri- O-benzyl-D-glucitol / 中国药科大学学报
Journal of China Pharmaceutical University
; (6): 205-208, 2009.
Article
in Zh
| WPRIM
| ID: wpr-480345
Responsible library:
WPRO
ABSTRACT
Aim: To improve the synthesis for 2, 5-anhydro-3,4, 6-tri-O-benzyl-D-glucitol. Methods: Dehydration of D-mannitol, followed by a reaction sequence of selective protection, benzylation, deprotection, tritylation, benzy-lation and removal of the trityl group, afforded the title compound. Results: Based on the improvement of the reported synthetic route, 2,5-anhydro-3,4,6-tri-O-benzyl-D-glucitol was synthesized in seven steps from D-mannitol with a total yield of 8. 3% . Conclusion: This new method features mild reaction conditions and facile work-up.
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WPRIM
Language:
Zh
Journal:
Journal of China Pharmaceutical University
Year:
2009
Type:
Article