Synthesis and antitumor activity of ent-kaurene diterpenoids / 中国药科大学学报
Journal of China Pharmaceutical University
;
(6): 20-25, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-480413
ABSTRACT
Aim:
To synthesize the ent-kaurene diterpenoid and its derivatives from natural available stevioside.Methods:
The crucial pharmacophore of exo-methylene ketone was designed and the carboxyl group at C-4 was modified.The cytotoxic inhibition activities in vitro of target compounds were evaluated against human cancer cells BEL-7402,HO-8910,MCF-7 and HL-60 by a MTT method.Results andConclusion:
The struc-tures of new target compounds were identified by ~1H NMR,FT-IR and EI-MS.The preliminary experimental re-sults showed that some derivatives of ent-kaurene diterpenoid possessed fair inhibitory activity against tumor cell lines compared with that of their parent steviol.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of China Pharmaceutical University
Year:
2010
Type:
Article
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