Therapeutic effects of ZK_(14), a novel nitric oxide donating biphenyldicarboxylate derivative, on hepatic fibrosis in rats / 中国药科大学学报
Journal of China Pharmaceutical University
;
(6): 254-257, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-480420
ABSTRACT
Aim:
To study the therapeutic effects of ZK_(14), a novel nitric oxide donor, on hepatic fibrosis in rats.Methods:
Rats were injected intraperitoneally with CCl_4 and induced to hepatic fibrosis, followed by intra-gasrtic administration with high dose of 20 mg/kg and low dose of 10 mg/kg of ZK_(14) for 4 weeks. The effects were evaluated in the content of nitric oxide of serum and nitric oxide synthases of liver, in serum levels of the hepatic functions indices and hepatic fibrotic index and in liver histopathology.Results:
The biochemical indices and pathology grade were effectively improved in the group of ZK_(14) 20 mg/kg, and liver function was also effectively protected in this group.Conclusion:
ZK_(14), a novel nitric oxide donating biphenyldicarboxylate derivative, showed preferable therapeutic effects on hepatic fibrosis of rats induced with CC14, and it may be of potential value in the treatment of hepatic fibrosis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of China Pharmaceutical University
Year:
2009
Type:
Article
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