Research progress of the molecular pathogenesis in myelodysplastic syndromes / 白血病·淋巴瘤
Journal of Leukemia & Lymphoma
;
(12): 510-512, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-480686
ABSTRACT
The pathogenesis-related genes of myelodysplastic syndrome (MDS) has became a hot spot in the whole world.The common genetic mutations in MDS include epigenetic regulator mutations (TET2,ASXL1,DNMT3A),RNA splicing mutations (SF3B1,SRSF2,U2AF1,ZRSR2),signal transduction regulators (NRAS,JAK2),transcription factors mutations (RUNX1,TP53) and so on.Each mutation plays an important role in the molecular mechanisms of the pathogenesis of MDS and is closely related with clinical phenotype,efficacy and prognosis.Further study of the molecular pathogenesis of MDS-related genes can promote exploring the mechanisms and new therapeutic strategies for MDS.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Etiology study
/
Prognostic study
Language:
Chinese
Journal:
Journal of Leukemia & Lymphoma
Year:
2015
Type:
Article
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