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Functional mechanism of the mutual regulation between long non-coding RNAs and other epigenetic mechanisms in cancer / 国际肿瘤学杂志
Journal of International Oncology ; (12): 671-674, 2015.
Article in Chinese | WPRIM | ID: wpr-480705
ABSTRACT
Abnormal expressions of long non-coding RNAs (LncRNAs) are associated with a variety of tumors.Recent studies show that lncRNA can regulate other epigenetic processes such as DNA methylation,histone modifications,chromatin remodeling and miRNA through various ways;on the other side,other epigenetic processes can influence the expression of lncRNA.The mutual regulation of them paly important roles in the occurrence and development of malignant tumors.The better understanding of the crosstalk between lncRNA and epigenetic modulation will contribute to clearly clarify the mechanism of tumor,which provides a theoretical basis for the anti-cancer therapies targeting lncRNAs.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Journal of International Oncology Year: 2015 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Journal of International Oncology Year: 2015 Type: Article