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Study of proton magnetic resonance spectrum on cerebral white matter lesions in patients with Alzheimer's disease and vascular dementia / 中华行为医学与脑科学杂志
Article in Zh | WPRIM | ID: wpr-480894
Responsible library: WPRO
ABSTRACT
Objective To evaluate the value of proton magnetic resonance spectrum (1H-MRS) in the differential diagnosis of Alzheimer's disease (AD) and vascular dementia (VD) patients with white matter lesions (WMLs).Methods Multi voxel 1H-MRS were performed to 30 patients with AD,30 patients with VD,and 30 normal control volunteers.The levels of the N-acetylaspartate (NAA),myo-inositol (mI),glutamate (Glu),and creatine (Cr) were measured in the white matter adjacent to the lateral ventricles.The ratios of NAA/Cr,mI/Cr and Glu/Cr were calculated and compared among the group.Comparisons of the 1H-MRS indexes among AD,VD and NC group were conducted by one-way ANOVA.Results NAA/Cr ratios of the region of interesting in AD (1.59±0.15)and VD(1.53±0.12) group were significantly decreased compared with NC (1.79±0.22)group (P<0.05),and Glu/Cr ratios of the region of interesting in AD(0.41±0.03) and VD(0.49±0.04) group were significantly decreased compared with NC(0.57±0.05) group (P<0.05).However,there were not significant differences for NAA/Cr ratios of the paraventricular white matter region between AD and VD group (P>0.05),and Glu/Cr ratios in AD and VD groups were significantly different (P<0.05).A significantly increased mI/Cr was found in AD (0.68±0.05) group than in VD(0.57±0.04) and NC(0.55±0.03) groups (P<0.05),and there were no significant changes in mI/Cr ratios between VD and NC groups (P>0.05).Conciusion Multi-voxel 1H-MRS is an effective method in the differential diagnosis of dementia,and changes of the mI/Cr and Glu/Cr ratios of the white matter adjacent to the lateral ventricles may help to identify the AD and VD patients.
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Full text: 1 Index: WPRIM Language: Zh Journal: Chinese Journal of Behavioral Medicine and Brain Science Year: 2015 Type: Article
Full text: 1 Index: WPRIM Language: Zh Journal: Chinese Journal of Behavioral Medicine and Brain Science Year: 2015 Type: Article