Influence factors analysis of acute-on-chronic liver failure effects of chronic hepatitis B virus infection / 中国综合临床

ABSTRACT

Objective To investigate the influence factors of chronic hepatitis B virus(HBV) infection complicated with chronic liver failure.Methods One hundred and eighty-six chronic HBV infection patients with chronic liver failure were selected as our subjects,who were hospitalized in the Affiliated Hospital of Hebei United University from Jul.2008 to Dec.2013 and they served as case group.Meanwhile,186 patients with chronic HBV infection were selected and served as control group,who were hospitalized during the same period.A self-mad questionnaire was used to collect the information.The influence factors related to HBV infection complicated with acute on chronic liver failure were recorded.Results Multivariate conditional Logistic regression analysis showed that 8 variables were risk factors in terms of chronic HBV infection complicated with acute on chronic liver failure and they were virus overlap infection (OR =6.523,95％ CI2.034 -10.030),drug application (OR =9.012,95％ CI3.018-13.241),alcohol (OR =7.2520,95％ CI1.985 -11.247),bacterial infection(OR =4.378,95％ CI2.032-5.648),surgical operation (OR =8.514,95％ CI2.114-17.253),emotional stress and fatigue (OR =2.217,95％ CI1.729-5.648),genetic (OR =11.124,95％ CI2.168-13.429),high PCR-HBVDNA quantity (OR =1.628,95％ CI1.504-3.282).And one protective factorwas the usage of antiviral drug(OR=0.163,95％CI0.085-0.417).Conclusion The risk factors include virus over infection,application of hepatotoxic drugs,disease before drinking,bacterial infection,surgical operation,emotional stress and fatigue,the genetic parents and high PCR-HBVDNA quantification;and antiviral drugs application is the protective factor in terms of Chronic HBV infection complicated with acute-on-chronic liver failure.