Research advances in NLRP3 inflammasome / 基础医学与临床

ABSTRACT

Inflammasomes are multiprotein complexes that can recognize pathogenic microorganisms and stress -asso-ciated endogenous molecules and play an important role in innate immune system .Inflammasomes cause inflamma-tion response by inducing maturation of inflammatory cytokines interleukin ( IL)-1βand IL-18 through activation of caspase-1 ,and involve in the pathogenesis of various diseases such as cryopyrin-associated periodic syndrome , is-chemia-reperfusion injury and atherosclerosis .