Analysis of CYP2C19 gene polymorphism among different sex,age,and BMI in the southeast of Henan province / 中国基层医药

ABSTRACT

Objective To study the frequency of CYP2C19 genotype and allele mutation of cytochrome P450 in the southeast part of Henan province,and to understand the effect of sex,age,body mass index (BMI)on the genetic polymorphism of CYP2C19.Methods Genetic polymorphism analysis of CYP2C19 gene in 161 healthy people in Henan province,using gene chip method,87 male,74 female,aged 26 -82 years old,and BMI 17 -31. Results The experiment,a total of CYP2C19 six different gene mutation type,CYP2C19 1 of (40.4%),CYP2C19*1 /*2 (39.1%),CYP2C19 *2 /*2 (14.9%),CYP2C19 *1 /*3 (3.1%),CYP2C19 *2 /*3 (2.5%), CYP2C19*3 /*3 (0%);allelomorph CYP2C19 * 2 (35.7%),follow (2.8%).87 male wild type homozygous for CYP2C19 1 of (39.1%),allelomorph CYP2C19 * 2 (39.1%),follow (3.1%),74 female wild type homozygous for CYP2C19 1 of (41.9%),and other allelomorph CYP2C19 * 2 (32.3%),follow (2.5%).103 cases were more than or equal to 58 years old wild type homozygous for CYP2C19 1 of (47.6%),allelomorph CYP2C19 * 2 (39.8%),follow (3.7%),58 25 groups of wild -type homozygous for CYP2C19 1 of (37.7%),allelomorph CYP2C19 * 2 (32.9%),follow (1.2%),BMI <25 groups of wild -type homozygous for CYP2C19 1 of (42.4%),and other allelomorph CYP2C19 * 2 (38.5%),follow (4.3%).Conclusion There was no significant difference in the genotype of CYP2C19*2 between the BMI and *3 in the southeast part of Henan province.