Research advances of recombinant coagulation factor VII expression and synthesizing mechanism / 中国药科大学学报
Journal of China Pharmaceutical University
; (6): 623-628, 2015.
Article
in Zh
| WPRIM
| ID: wpr-481926
Responsible library:
WPRO
ABSTRACT
Haemophilia is caused by lack of coagulation factor VIII or IX in patients′blood with inadequate hemostasis.Currently recombinant coagulation factor VII(rFVII)produced in different cells is used against clini-cal bleeding of haemophilia patients.To enhance the production and activity of rFVII;some eukaryotic cells such as baby hamster kidney(BHK);Chinese hamster ovary(CHO);insect cell and fish embryo;were used to express rFVII.Meanwhile;the effect of functional gene on the activity of rFVII and the limitation of rFVII production caused by post-translational modification were investigated by different methods.The role of rFVII in hemostasis;synthesis of rFVII in different eukaryotic cells and impact on production of post-translational modification are reviewed in this article.
Full text:
1
Index:
WPRIM
Language:
Zh
Journal:
Journal of China Pharmaceutical University
Year:
2015
Type:
Article