Your browser doesn't support javascript.
loading
Impact of -1304T→G polymorphism in MKK4 promoter on prognosis of colorectal cancer cases receiving adjuvant cheomotherapy / 实用医学杂志
The Journal of Practical Medicine ; (24): 2988-2991, 2015.
Article in Chinese | WPRIM | ID: wpr-482259
Responsible library: WPRO
ABSTRACT
Objective To analyze the impact of rs3826392 polymorphism in MKK4 promoter on prognosis of colorectal cancer cases (CRC) receiving adjuvant chemotherapy. Methods The associations between rs3826392 genotype of 203 CRC cases receiving adjuvant chemotherapy and clinicopathologic factors,overall survival (OS), disease free survival (DFS) were analyzed retrospectively. Results No association was found between rs3826392 genotype and clinicopathologic factors (P > 0.05). TG+GG genotype had better OS (P = 0.018) and DFS (P =0.019) when compared with TT genotype. Cox multivariate model showed rs3826392 TG+GG genotype remained independent favorable factor for OS(HR = 0.389;95%CI = 0.177-0.855) and DFS(HR=0.491;95%CI = 0.271-0.890) respectively. Conclusion -1304G variant genotypes (i.e., TG+GG) in rs3826392 may be the biomarker of better prognosis in CRC receiving adjuvant chemotherapy.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: The Journal of Practical Medicine Year: 2015 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: The Journal of Practical Medicine Year: 2015 Type: Article