Verification of the clinical applicability of the published standard reference interval based on health examination results of Han and Uygur populations / 国际检验医学杂志

ABSTRACT

Objective To verify the clinical applicability of the published standard intervals of routine clinical chemistry (WS/T404 .1‐2012 ,WS/T404 .2‐2012) based on the health examination results of Han and Uygur populations in Urumqi .Methods This was a retrospective study .The results of serum TP ,ALB ,ALT ,AST ,ALP ,GGT from healthy examination individuals of Han and Uygur populations (from 2013 August to 2015 January) were collected and the healthy cases (age range20 -79 years old) were chosen to calculate the 2 .5% and 97 .5% percentiles ,excluding the significant abnormal results according to the Medical Deciding Level 2 recommended by Staland .The percents of health cases not falling in the published standard interval were calculated to meet the judgment criterion of verification (<10% ) .Results The test of normality revealed that the Han and Uygur's results of all veri‐fied items were skewed distributions .The 2 .5% and 97 .5% percentiles of the results of two populations were as follows ,TP(Han 65 -81 g/L ;Uygur 64-81 g/L) ,ALB(Han 41-53 g/L ;Uygur 40-52 g/L) ,ALT(Hanmale 9-51 U/L and female 7-42 U/L ;Uygurmale 9-53 U/L and female 6-43 U/L) ,AST(Hanmale 14-42 U/L and female 12-37 U/L ,Uygurmale 12-42 U/L and female 12-38 U/L) ,ALP(Hanmale 45-119 U/L ;Uygurmale 47-122 U/L) ,ALP(female 20-49 years oldHan 35-95 U/L and Uygur 40-104 U/L) ,ALP(female 50-79 years oldHan 43-131 U/L and Uygur 51-132 U/L) ,GGT(Hanmale 11-71 U/L and female 8-54 U/L ;Uygurmale 11 -73 U/L and female 7 -55 U/L ) .The percents of AST results for Han's male , Uygur's male and Uygur's female not falling in the published standard reference interval were slightly over 10% ,but AST results o‐ver 10% were mainly under the lower limit of the published standard reference interval .The health case percents for the other veri‐fied items of Han and Uygur populations not falling in the published standard reference interval were under 10% .Conclusion The published standard reference intervals of routine clinical chemistry (WS/T404 .1‐2012 ,WS/T404 .2‐2012) are applicable in our la‐boratory for the detection of Han and Uygur population .