Research of cognitive function and influencing factors in first-degree relatives of elderly schizophrenia / 重庆医学

ABSTRACT

Objective To investigate the cognitive function and its influencing factors in first-degree relatives of elderly schiz-ophrenia.Methods Totally 30 cases of healthy children with elderly patients with schizophrenia(a family group ),50 cases of pa-tients with schizophrenia(patient group),52 healthy elderly subjects (health group)all accepeted mini-mental state examination (MMSE),clinical memory scale(CMS),wisconsin card sorting test(WCST),trail making test(TMT-A),number sign(DSy)and digit span(DSp)tests.The influencing factors were analyzed by stepwise multiple regression analysis method.Results The MMSE score,MQ,connection time,DSy points,and DSp scores of kinship group were significantly higher in patients group(P 0.05),and its completed categories,connec-tion time was significantly lower than the normal group (P < 0.05 ).Years of education and BEAM were incorporated into the MMSE,the number of sustained response were the dependent variable regression equation,the coefficient of determination R 2 was 0.276 and 0.422,Life events,BEAM,personality,parent-child relationship,previous occupation MQ were the dependent variable in-to the regression equation,R 2 was 0.475.Years of education and MMSE score,MQ were significant positive correlation(P <0.05), and sustained response were significantly negatively correlated(P <0.01);BEAM and sustained response were significantly correla-ted(P <0.01);age and completed categories were significantly negatively correlated and the connection time is significant positive correlation(P <0.05);life events,parent-child relationship were significant negative correlation with MQ(P <0.05).Conclusion First-degree relatives of elderly schizophrenia have obvious executive dysfunction,the impact of factors including years of education, BEAM and age.