Predictive value of NT-proBNP in anthracycline-based chemotherapy-related cardiotoxicity of breast cancer / 中国医师杂志
Journal of Chinese Physician
;
(12): 1516-1519, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-482790
ABSTRACT
Objective To explore the predictive value of serum N-terminal pro-brain natriuretic peptide (NT-proBNP) level in anthracycline-based chemotherapy-related cardiotoxicity of breast cancers.Methods A total of 135 breast cancer patients was analyzed if NT-proBNP was associated with chemotherapy-related cardiotoxicity.The level of NT-proBNP in the diagnosis of cardiotoxicity was assessed.Results A total of 22 patients (16.29%) had subsequent claims for cardiotoxicity events.NT-proBNP in cardiotoxicity group was significantly higher than that non-cardiotoxicity group (P < 0.05).According to receiver operating characteristic (ROC) curve, the cut-off value of NT-proBNP was set at 350 pg/ml, specificity and sensitivity were 70.32% and 82.58% , respectively.Positive and negative predictive values were 78.12% and 65.45%, respectively.Conclusions The present study is to confirm excellent clinical value of NTproBNP on cardiotoxicity.The level of NT-proBNP for early detection of cardiotoxicity has good prospects for high risk patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
/
Screening study
Language:
Chinese
Journal:
Journal of Chinese Physician
Year:
2015
Type:
Article
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