Progress on the clinical research of fluoro-3(2(S)-2-azetidinylmethoxy) pyridine and Iodo-3-(2(S)-azetidinylmethoxy) pyridine / 中华核医学与分子影像杂志

ABSTRACT

Neuronal nicotinic acetylcholine receptors (nAChRs) are involved in a spectrum of cognitive functions and related to some psychiatric and neurodegenerative disorders such as AD,PD,autosomal dominant nocturnal frontal lobe epilepsy and schizophrenia.Nuclear medicine imaging of neuronal nAChRs in living human is a relatively new field.Halogenated analogs of 3 (2 (S)-2-azetidinylmethoxy) pyridine (A-85380) are the most widely used brain imaging radiotracers.In this review,the progress on the latest research on SPECT and PET using the analogs of A-85380 is summarized.