Association between serum leptin, adiponectin, visfatin, obesity and hypertension in female / 中华内科杂志

ABSTRACT

Objective This study was aimed to investigate the relationship between serum leptin,adiponectin,visfatin levels and obesity and essential hypertension in female subjects.Methods According to BMI and blood pressure,206 female participants enrolled were divided into four groupsgroup 1obesity and hypertension (48 cases);group 2non-obesity but hypertension (48 cases);group 3obesity and normotension (56 cases) and group 4normal BMI and blood pressure (54 cases).Serum leptin,adiponectin and visfatin levels were detected and their relationships to BMI,blood pressure and waist circumference were analysed.Results Serum leptin levels were significantly higher in non-obese groups [group 2(4.47 ±1.26) ng/L,group 4(3.73-±1.18)ng/L] than in obese groups [group 1(2.97 ± 1.46) ng/L,group 3(3.02 ± 1.18) ng/L],and higher in hypertension groups than in normotension groups.Serum adiponectin levels were obviously higher in group 4 [38.99 (19.75,103.71) μg/L] than in the other three groups.There were no significant differences in adiponectin levels among group 1,2 and 3.Serum levels of visfatin were lower in normotension groups [group 33.19 (0.96,9.45) ng/L;group 43.23 (1.92,4.64) ng/L] than in hypertension groups [group 13.84 (3.40,5.35) ng/L;group 23.75 (1.63,6.67) ng/L] irrespective of obesity.Logistics regression analysis showed that there was 1.6％,8.3％,or 5.45％ increased risk for hypertension for each 1 μg/L decrease in adiponectin,1 cm increase in waist circumference,or 1 μg/L increase in visfatin level in obesity,respectively.No relationship could be viewed between leptin and hypertension.Conclusions Adiponectin and visfatin levels were correlated with obesity and blood pressure in females.Both adipokines may play a crucial role in the development of hypertension in female obesity.