Correlation of high density lipoprotein cholesterol with resistance of epidermal growth factor receptor-tyrosine kinase inhibitor in advanced non-small-cell lung cancer / 肿瘤研究与临床
Cancer Research and Clinic
;
(6): 649-654, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-483034
ABSTRACT
Objective To explore the relevance of high density lipoprotein cholesterol (HDL-C) level and resistance of epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) in advanced non-small cell lung cancer (NSCLC).Methods In a total of 87 NSCLC patients harboring EGFR mutation treated with EGFR-TKI, the correlations of pre-treatment levels of soluble HDL-C between efficacy and resistance of EGFR-TKI were analyzed by Kaplan-Meier method and Cox proportional hazard model.Results Patients with normal HDL-C (≥0.94 mmol/L) had a better disease control rate (DCR) than those with low HDL-C (<0.94 mmol/L) [94.5 % (52/55) vs 65.7 % (21/32), P < 0.001].The results of univariate analysis showed that patients with normal HDL-C had longer progress free survival (PFS) (HR =0.27, 95 % CI 0.164-0.444, P < 0.001).The results of multivariate Cox proportional hazard model analysis with sex, pathologic histology, smoking history and mutation type showed that only HDL-C group had a significant difference (P < 0.001).The same results were showed when stratified by sex and smoking history (female P < 0.001, male P =0.002;Smoker P < 0.001, non-smoker P =0.014).Conclusion Normal pre-treatment serum levels of HDL-C are associated with a better outcome and longer progression-free survival in NSCLC patients treated with EGFR-TKI, which may be a predictive marker for a better response.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Cancer Research and Clinic
Year:
2015
Type:
Article
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