Progress of the pathogenesis of focal segmental glomerulosclerosis / 国际儿科学杂志

ABSTRACT

Focal segmental glomerulosclerosis (FSGS) is the main pathologic type that causes end-stage kidney diseases and the recurrence after kidney transplantation.So far, the pathogenesis of FSGS is still not entirely clear.However, more and more mutations have been reported on the FSGS, especially on the genetic FSGS.It is clear that podocyte plays an important role in the development of FSGS.At the same time, the role of soluble urokinase-type plasminogen activator receptor in the recurrence after kidney transplantation has become the research focus.This article will make a brief review on the progress of the pathogenesis of FSGS.