Prognostic Value of Soluble ST2 During Hospitalization for ST-Segment Elevation Myocardial Infarction
Annals of Laboratory Medicine
;
: 313-319, 2016.
Article
in English
| WPRIM
| ID: wpr-48340
ABSTRACT
BACKGROUND:
Studying the role of soluble ST2 (sST2) during hospitalization for myocardial infarction (MI) can be helpful for predicting the course of the hospitalization and development of complications.METHODS:
We included 88 patients with MI (median age, 58 yr). Depending on the course of the hospitalization, the patients were divided into two groups the favorable (n=58) and unfavorable (n=30) outcome groups. On days 1 and 12 after MI, serum sST2 and N-terminal pro-brain natriuretic peptide (NT-proBNP) were measured by ELISA.RESULTS:
On day 1, the concentrations of sST2 and NT-proBNP increased 2.4- and 4.5-fold, compared with the controls. Measurements on day 12 showed a significant decrease in the sST2 level (P=0.001), whereas the NT-proBNP level did not change. On day 1, the sST2 level in the unfavorable outcome group was 2-fold higher than that in the favorable outcome group and 3.7-fold higher than in the controls. On day 12, the marker level decreased in both groups. On day 1, the NT-proBNP level in the unfavorable outcome group was 6.8-fold higher than in the controls and 1.8-fold higher than in the favorable outcome group. On day 12, the level of NT-proBNP remained elevated in both groups. Determining the levels of both sST2 and NT-proBNP increases their diagnostic significance (odds ratio [OR], 1.92; 95% confidence interval [CI], 1.7-3.2; areas under curve [AUC] 0.89; P=0.004).CONCLUSIONS:
The level of sST2 is a more sensitive indicator during MI hospitalization than NT-proBNP.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Peptide Fragments
/
Prognosis
/
Enzyme-Linked Immunosorbent Assay
/
Case-Control Studies
/
Logistic Models
/
Odds Ratio
/
Proportional Hazards Models
/
ROC Curve
/
Receptors, Somatostatin
/
Area Under Curve
Type of study:
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Annals of Laboratory Medicine
Year:
2016
Type:
Article
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