Advances in nucleotide reductase inhibitors for antiviral therapy / 中华临床感染病杂志
Chinese Journal of Clinical Infectious Diseases
;
(6): 83-86, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-483483
ABSTRACT
Ribonucleotide reductase ( RR ) is a rate-limiting enzyme, and it is responsible for reducing ribonucleotides to their corresponding deoxyribonucleotides , which are the building blocks required for DNA replication and repair .Recent studies have revealed that RR activity is associated with DNA replication in virus , and RR inhibitors have been used for clinical antiviral treatment .This paper reviews research progress on RR and its inhibitors , including the classification , structure and function of RR; the classification, mechanism and clinical application of RR inhibitors in antiviral therapy and the future prospects of RR inhibitors .
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Clinical Infectious Diseases
Year:
2016
Type:
Article
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