One case of a thyrotropin-secreting microadenoma and resistance to thyroid hormone with P453T mutation in TRβgene / 中华内分泌代谢杂志
Chinese Journal of Endocrinology and Metabolism
;
(12): 19-23, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-483485
ABSTRACT
[Summary] We investigated a 12-year-old girl with elevated serum FT3 , FT4 , and TSH levels. The sequence of thyroid hormone receptorβ( TRβ) exons revealed a CCT→ACT transition mutation at nucleotide 453 site within exon10,whichresultedinthesubstitutionofcytosinetoadenosinein(P453T). Pituitarymagneticresonanceimage showed a pituitary micoradenoma. The patient underwent transsphenoidal pituitary adenomectomy. Pathological results exhibited positive TSH-β, GH, prolactin, ACTH, and α-HCG staining for the tumor. This is the first case report with thyroid hormone resistance syndrome and thyrotropin-secreting adenoma.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Endocrinology and Metabolism
Year:
2016
Type:
Article
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