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Association between CMTM5 gene rs723840 single nucleotide polymorphism and high on asprin platelet reactivity / 北京大学学报(医学版)
Journal of Peking University(Health Sciences) ; (6): 905-909, 2015.
Article in Chinese | WPRIM | ID: wpr-483512
ABSTRACT

Objective:

To elucidate the correlation between the single nucleotide polymorphism of CKLF-like MARVEL transmembrane member 5 ( CMTM5 ) gene rs723840 and the occurrence of high on aspirin platelet reactivity ( HAPR) .

Methods:

The present study is a case-control study. A total of 210 hospitalized patients in Peking University First Hospital were enrolled. Aspirin response was assessed by 0. 5 g/L arachidonic acid (AA)-induced platelet aggregation ratio (PR), and ≥3/4 quartile of PR of the population was defined as HAPR. Accordingly all the enrolled 210 coronary artery diseases ( CAD) patients were divided into HAPR group and No-HAPR group. The genotypes were determined by poly-merase chain reaction ( PCR) and sequencing analysis for rs723840 of CMTM5 gene.

Results:

The geno-type frequencies in rs723840 C>T of CMTM5 gene conformed well to the Hardy-Weinberg equilibrium in both HAPR group and No-HAPR group. Between the two groups, the genotypes frequencies in HAPR and No-HAPR groups were 48 . 4%, 51 . 6%, 0 . 0% and 73 . 7%, 22 . 9%, 0 . 034%, respectively ( P=0. 004). The C, T allele frequencies were significantly different in the two groups (P =0. 031,OR =0 . 501 , 95%CI0 . 264-0 . 947 ) .

Conclusion:

Our study finds a significant correlation between CMTM5 gene rs723840 polymorphism and high on aspirin platelet reactivity.

Full text: Available Index: WPRIM (Western Pacific) Type of study: Observational study / Risk factors Language: Chinese Journal: Journal of Peking University(Health Sciences) Year: 2015 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Type of study: Observational study / Risk factors Language: Chinese Journal: Journal of Peking University(Health Sciences) Year: 2015 Type: Article