The target/no target ratio analysis of 18F-FDG uptaking in head and neck malignancy by SPECT/CT coincidence imaging / 天津医药

ABSTRACT

Objective To investigate the influencing factors of 18F-FDG uptaking in head and neck malignancy by SPECT/CT coincidence imaging. Methods 18F-FDG SPECT/CT coincidence imaging was performed in 32 patients with head and neck malignancy after surgery, radiotherapy or radiotherapy + chemotherapy. The radio of target/no target (T/N) was calculated. The gender, age, fasting blood glucose level, size of tumor, location of tumor, pathological classification, de-gree of cell differentiation and treatment modalities were analyzed between groups. Results The single-factor analysis of variance showed that the T/N value was significantly higher in >70 yeas old, group than that of 41-50 yeas old group and 51-60 yeas old group (P5 cm group (P0.05). The multiple linear regression analysis showed that 18F-FDG uptaking in head and neck malignancy (T/N=Y) was related to the age of patients (X2), the diameter of tumor (X4) and the degree of cell differentiation (X9) =-4.389 25+0.053 03 X2+1.617 86 X4+0.718 35 X9. Conclusion Tumor recurrence is more likely to occur in patients with age>70 years old, the diameter of tumor≥2 cm, and the anaplastic head and neck malignancy.We should pay much attention to the diagnosis and follow-up for these pa-tients.