The Role of SIRT1 in Central Nervous System / 대한정신약물학회지

ABSTRACT

Silent mating type information regulation 2 homolog 1 (SIRT1) is a nicotinamide adenosine dinucleotide (NAD+)-dependent class III histone deacetylase and is distributed in central nervous system and peripheral tissue. SIRT1 interacts with various transcription factors and cofactors by histone deacetylation and is involved in the modulation of food intake, energy metabolism, circadian rhythms, learning and memory, neurogenesis and neuroprotection. Increased or decreased SIRT1 activity or levels by pharmacological treatment or in genetic animal models have demonstrated its function and role in Central Nervous System and peripheral tissue. Recent study suggests that dysregulation of SIRT1 may be involved in anxiety or depression, but relatively little is known about the involvement of SIRT1 in anxiety or depression. Therefore, through unraveling the functional role of SIRT1 in food intake, energy metabolism, learning and memory as well as neuropsychiatric disease, studies on SIRT1 can shed light on the new drug development in treating neurodegenerative disease, metabolic disorder and neuropsychiatric disorder.