Research Progress of MicroRNA-193b and Obesity / 世界科学技术-中医药现代化

ABSTRACT

MicroRNAs (miRNAs) were found as a species of small non-coding single-stranded RNA molecules with the size of 20 to 25 nucleotides in recent years, which featured highly conserved and endogeny. It depredated and inhibited the target mRNA translation by complementary base pairing with the target mRNA. According to the latest study, miRNA was closely related with obesity, type 2 diabetes and other metabolic diseases. Obesity had became a major public health problem worldwide, which showed as an unusual increase in both the number and size of fat cells based on excessive accumulation of fat lead by the body’s energy metabolism imbalance of a metabolic disease. Among them, miRNA-193b-365 had an abnormal expression in adipocyte differentiation and obesity status. It might be involved in adipocyte differentiation and the development of obesity. Thus, it was of great significance to do a deep research in the understanding adipocyte differentiation mechanism to prevent and treat obesity. This paper reviewed research progress in this field.