Expression Pattern of Ki-67 and Apoptosis in Low grade Adenoma of Stomach and Colon / 대한암학회지

ABSTRACT

PURPOSE: Gastrointestinal carcinomas usually evolve through a series of well defined histologic steps. This concept of carcinogenesis is a multistep process involving progressive loss of growth control as well as an expansion and shift of cell proliferation. The cell proliferations and kinetics of normal gastrointestinal tract are well known. But, the cell kinetics of adenoma in gastrointestinal tract is poorly understood. This study was designed to evaluate the cell kinetics of low grade adenoma in stomach and colon. MATERIALS AND METHODS: The study was carried by the TUNEL method for the apoptosis and immunohistochemical staining for the Ki-67 using the formalin fixed paraffin embedded tissues. RESULTS: The mucosal locations of apoptotic cells and Ki-67 immunoreactive cells were irregular in gastric adenoma. The Ki-67 immunoreactive ceils were located in the base of colonic adenoma. Apoptotic cells were located in the luminal surface of the colonic adenoma, CONCLUSION: Above results indicate that most cells of the colonic adenoma move toward the lumen, corresponding to the base and lumen in low grade adenoma of stomach.