Analysis the risk factors of the mild cognitive impairment secondary with the mild to moderate traumatic brain injury patients / 中国神经精神疾病杂志

ABSTRACT

Objective To investigate the risk factors of the mild cognitive impairment(Mild Cognitive Impair?ment,MCI)secondary to the mild to moderate traumatic brain injury patients. Method The clinical and neuroimaging da?ta from 106 patients with mild to moderate traumatic brain injury during July 1, 2014 to July 1 ,2015 were collected. Cog?nitive function in patients with head injury after three months was assessed using the Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), Addenbrooke improved cognitive assessment (ACE-R). The impact of the different lesions on cognitive function was analyzed using univariate and multivariate logistic regression with patients with secondary MCI as the dependent variable and brain tissue lesions as independent variables. Results Sixty-nine pa?tients had normal cognitive function whereas 30 patients had MCI. seven patients were lost to follow. Univariate logistic regression analysis did not revealed any significance in age and GCS scores (P>0.05), but revealed significances in multi?ple lesions, lesioned hemisphere, the lobar white matter lesions and the internal capsule involvement (P<0.05). Multivari?ate logistic regression analysis showed that the left hemisphere(P=0.029,OR=1.637,95%CI=1.348~2.169), temporal lobe area(P<0.001,OR=1.521,95%CI=1.240~2.203), anterior limb(P=0.024,OR=1.526,95%CI=1.107~2.329), multi? ple lesions(P<0.001,OR=1.936,95%CI=1.287~3.228)were the risk factors of MCI. Conclusion Lesions in the left hemisphere, bilateral frontal and temporal lobe area, internal capsule injury and multiple lesions damage are the risk fac?tors of the mild cognitive impairment secondary to the mild to moderate traumatic brain injury.