Effect of pre-treatment blood neutrophil-to-lymphocyte ratio on the prognosis of cervical cancer after rediation or concurrent chemoradiation / 实用医学杂志

ABSTRACT

Objective To evaluate the predictive value of NLR in response to radiation therapy alone or concurrent chemoradiation therapy and the prognostic outcome. Methods Pretreatment NLR was evaluated in 230 paitents, with clinically staged cervical cancer (Ⅰ~Ⅳ), received RT or CCRT therapy, Receiver operating characteristic curves were applied to establish optimal cutoff points, and all 230 patients were therefore divided into two groups based on the NLR value, and univariate and multivariate analyses were used to estimate radiation response, Kaplan-Meier method was used to estimate the OS and DFS. Results ROC curve analysis demonstrated the best cut-of values for NLR (≥ 2.84)for radiation response. Results of Cox regression showed that NLR was significantly associated with the overall survival (OS). The high NLR group was poor in 1-year OS and 3-year OS compared with those in the low NLR group (65.5% vs 86.2%,32.4% vs 62.5%;P < 0.001). Conclusions Pre-treatment blood NLR could predict a good response to RT or CCRT, and could be a useful biomarker for cervical cancer patients before RT or CCRT, with the merits including easy measurement, reproducible and unexpensive marker of systemic inflammation.