Effects of Montelukast Combined with Salmeterol Xinafoate and Fluticasone Propionate on the Efficacy, Serum IL-6 , IL-8 and IL-10 Levels in Asthma Patients / 中国药师

ABSTRACT

Objective:To discuss the effect of montelukast combined with salmeterol xinafoate and fluticasone propionate on serum IL-6, IL-8 and IL-10 levels in asthma patients. Methods:Totally 80 patients with asthma were randomly divided into the control group (n=42) and the observation group (n=38). The control group was treated with salmeterol xinafoate and fluticasone, and the observa-tion group was treated with the combination of montelukast and salmeterol xinafoate and fluticasone. The course of treatment was 9 months. The clinical efficacy and the changes of IL-6, IL-8 and IL-10 in the two groups were compared before and after the treatment. Results:The clinical total effective rate of the observation group was 92. 11%, which was significantly higher than that of the control group (73. 81%, P<0. 05). The correlation indices (FEV1, FEV1, PEF and FEV1/FVC) of the lung ventilation function in the ob-servation group were significantly higher than those in the control group (P<0. 05). Before and after the treatment, the differences in the levels of serum IL-6, IL-8 and IL-10 were statistically significant (P<0. 05), and the differences between the two groups were also statistically significant (P<0. 05). Conclusion: Montelukast combined with salmeterol and fluticasone propionate can significantly affect on the inflammatory factors in serum of patients with asthma, which should be used and popularized in clinics.