Early-noninvasive measurements about endothelial function in obese children / 国际儿科学杂志

ABSTRACT

Along with the high prevalence of obesity in children and adolescents,obesity can lead to im-paired glucose tolerance,dyslipidemia,elevation of blood pressure,the risk of metabolic syndrome,diabetes,and cardiovascular and cerebrovascular diseases gradually increases.As end-event cardiovascular disease(CVD)is hardly present in childhood,there is a critical need for early markers to assess,predict,and treat the children who are vulnerable to developing CVD.For mitigating the incidence of future CVD through early detection and pre-vention programs,this paper reviews the relationship between endothelial dysfunction and immunologic dysfunc-tion,chronic inflammation,oxidative stress,insulin resistance.And it also provides a critical overview on early-noninvasive measurements about endothelial function in obese children.