Research progress on ion channels in human glioma / 肿瘤研究与临床

ABSTRACT

Glioma is a serious threat to human health.Increasing evidences indicate that abnormal expression and activities of a number of ion channels,e.g.voltage-gated K+,Ca2+,C1-channels,are involved in the growth,proliferation,migration and invasion of glioma cells.Ion channels may affect the occurrence and development of glioma cells through regulating the membrane potential,adjusting the cytoplasmic volume,ion concentration,and pH value.In-depth understanding the role of ion channels in formation,development and transfer process of glioma may provide new targets for glioma prevention and treatment.In this paper,the advanced studies of ion channels in glioma were briefly reviewed.