Allogenic chondrocytes-polyglycolic acid compound for repair of thyroid cartilage defects / 中国组织工程研究
Chinese Journal of Tissue Engineering Research
;
(53): 1711-1717, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-485687
ABSTRACT
BACKGROUND:
Tissue-engineered bone can be obtained by the combination of chondrocytes and polyglycolic acid scaffold.OBJECTIVE:
To investigate the effect of alogeneic chondrocytes/polyglycolic acid scaffold compound in the repair of thyroid cartilage defects in rabbits.METHODS:
Twenty New Zealand adult rabbits were randomly divided into experimental group with implantation of alogeneic chondrocytes/polyglycolic acid scaffold compound and control group with implantation of polyglycolic acid scaffold. Gross and histological observations were done at 4 and 8 weeks after implantation. RESULTS ANDCONCLUSION:
(1) Gross observationresults:
4 weeks after surgery, cartilage defects in the experimental group were repaired certainly, and no necrosis appeared in the repair area; in the control group, the defects were filed with muscle and connective tissues. At 8 weeks after implantation, cartilage defects in the experimental group were further repaired, with unclear repair boundaries, and in the control group, cartilage defects were no repaired and showed a notable boundary with the surrounding normal cartilage tissues. (2) Immunohistochemical stainingresults:
the expression of type II colagen in the experimental group was higher than that in the control group (P < 0.05) at 4 and 8 weeks after implantation. These findings indicate that the alogeneic chondrocytes/polyglycolic acid scaffold compound can promote the repair of thyroid cartilage defects in rabbits.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Tissue Engineering Research
Year:
2016
Type:
Article
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