Analysis of One Case of Irinotecan-induced Delayed Diarrhea / 中国药师
China Pharmacist
;
(12): 543-545, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-485936
ABSTRACT
Objective:
To analyze one case of delayed diarrhea caused by irinotecan.Methods:
The pathogeny, mechanism, ge-netics and treatment of the case were analyzed.Results:
Delayed diarrhea was the dose-limited toxicity of irinotecan, which was related with the cytotoxicity of the active metabolite 7-ethyl-10-hydroxycamptothecin (SN-38). Genetic polymorphism was one of important risk factors, especially UGT1A1 polymorphisms could be used as a predictor for the diarrhea. The pharmacotherapy of the diarrhea was ef-fective and rational, and the clinical pharmacist provided rational pharmaceutical care for the patient.Conclusion:
It is very important to enhance pharmaceutical care for the patients treated with irinotecan.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
China Pharmacist
Year:
2016
Type:
Article
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