Effect of body mass index on outcomes of in vitrofertilization for infertile females at different ages / 中国组织工程研究

ABSTRACT

BACKGROUND:The effect of body mass index (BMI) on the outcomes ofin vitrofertilization (IVF) is controversial. Some scholars suggested that the higher BMI, the lower rate of pregnancy, and the higher rate of abortion. However, some others got the different results. To data, the effects of BMI on the pregnancy outcomes in females at different ages are rarely reported. OBJECTIVE:To explore the effect of BMI on the pregnancy outcomes of IVF for infertile women atdifferent ages. METHODS:A total of 902 cycles undergoing IVF were divided into two groups according to the age≤ or> 35 years old groups. The patients in each group were then divided into four subgroups according to BMI low weight, normal weight, excess weight, and obesity subgroups, respectively. RESULTS AND CONCLUSION: With increasing BMI, the average dosage of gonadotropins was increased gradualy in two both of age groups (P 35 years old group, the empty folicle rate in obesity subgroup was significantly higher than that in normal weight subgroup (P 0.05). These findings suggest that in the females at the younger age, BMI not only affects the quality of folicles and fertilization rate; but with increasing BMI, clinical pregnancy rate is decreased obviously. However in the females at the older age, BMI only affects the folicular quality, embryo quality and fertilization rates; there are no significant differences in the outcomes of pregnancy in the four subgroups. BMI have effects on pregnancy outcomes of IVF, and the effects are much greater in the younger female group.