Efficacy of Zegui Longshuang capsules combined with clarithromycin sustained release tablets for elderly prostatitis and impact on inflammatory cytokines in prostatic fluid / 中国生化药物杂志

ABSTRACT

Objective To investigate the effects of IL-2, IL-6 and IL-1βlevels in prostatic fluid by Zegui Longshuang capsules combined with clarithromythin sustained release tablets in elderly patients with prostatitis.Methods A total of 116 elderly patients with chronic prostatitis from our hospital were collected, patients or family members signed an agreement, and randomly divided into experimental group and control group with 58 cases in each group.Patients in control group were treated by clarithromycin sustained-release tablets, patients in the experiment group were treated by Zegui Longshuang capsules combined with clarithromycin sustained release tablets, treated for 30 d, compared the prostatic fluid leucocyte, lecithin bodies and IL-1β, IL-6, IL-2 changed of the two groups patients before and after treatment.At the same time, compared clinical efficacy and complications. Results The clinical effective rate of the control group 74.14% was lower than the experiment group 89.66%, with statistical significance (P<0.05);the prostatic fluid leucocyte and lecithin bodies of the experiment group improved situations were better than the control group after treatment, the IL-1β, IL-6, IL-2 and TNF -a levels in prostatic fluid of the experiment group were lower than the control group, with statistical significance (P<0.05), and the total adverse reactions rate of the two groups with no difference.Conclusion Zegui Longshuang capsules combine with clarithromycin sustain release tablets can significantly reduce the prostatic fluid of IL-2, IL-6 and IL-1βlevels in elderly prostatitis, the effect is obvious.