Effects of recombinant human interleukin-11 on the vaginal epithelium mitosis of estrone periodical mice and the expression of PCNA / 中国生化药物杂志
Chinese Journal of Biochemical Pharmaceutics
;
(6): 49-51, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-486431
ABSTRACT
Objective To investigate the therapeutic effects of recombinant human interleukin-11 (rhIL-11) on the vaginal epithelium mitosis of estrone periodical mice and the exprssion of PCNA.Methods The vaginal epithelium mitosis of estrone periodical mice was used as the epidermis hyperplasia model, rhIL-11 action in regulating the epidermis hyperplasia was observed and the expression of PCNA was detected by immunohistochemistry.Results The rhIL-11 significantly inhibited the mitosis of mouse vaginal epithelium, decreased the expression of PCNA ( P <0.01).Conclusion The rhIL-11 has good efficacy in treating the epidermis hyperplasia of psoriasis by inhibiting the mitosis of epithelium and decreasing the expression of PCNA.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Biochemical Pharmaceutics
Year:
2016
Type:
Article
Similar
MEDLINE
...
LILACS
LIS