Cigarette Smoke-Induced Interleukin-1 Alpha May Be Involved in the Pathogenesis of Adult Acne
Annals of Dermatology
;
: 11-16, 2014.
Article
in English
| WPRIM
| ID: wpr-48651
ABSTRACT
BACKGROUND:
Lipid peroxide (LPO) in comedones, which are produced as a result of sebum oxidation, might potentially induce interleukin-1alpha (IL-1alpha) and exacerbate comedogenesis and inflammatory changes in comedones.OBJECTIVE:
To investigate the relationship of proinflammatory cytokines and LPO levels in the extracts of comedones with the acne of clinical difference between smokers and non-smokers, and with the severity and distribution of the acne lesions.METHODS:
Twenty-two non-smoking and 21 smoking adult acne patients were evaluated by comedone extraction and measurement of proinflammatory cytokines and LPO levels. Acne severity and distribution of the lesions were also analyzed.RESULTS:
Relative to the non-smoking group, smokers had significantly higher levels of IL-1alpha and LPO in comedones. Their levels showed a positive correlation. However, there were no statistically significant difference between the severity or distribution of the disease and the levels of LPO and IL-1alpha in comedones.CONCLUSION:
Smoking may be involved in the pathogenesis of adult acne by increasing the oxidative stress that results in subsequent accumulation of LPO in comedones.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Smoke
/
Sebum
/
Smoking
/
Cytokines
/
Interleukin-1
/
Acne Vulgaris
/
Oxidative Stress
/
Interleukin-1alpha
/
Tobacco Products
Type of study:
Etiology study
Limits:
Adult
/
Humans
Language:
English
Journal:
Annals of Dermatology
Year:
2014
Type:
Article
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