The significance of BNP and D-dimer tests in thrombolytic therapy for patients with acute myocardial infraction / 国际检验医学杂志

ABSTRACT

Objective To investigate the significance of plasma B‐type Natriuretic Peptide(BNP) and D‐dimer test in thrombo‐lytic therapy for patients with acute myocardial infraction(AMI) .Methods Determinated the plasma levels of D‐dimer and BNP in patients diagnosed with AMI in the hospital by using full automatic immune fluorescence analyzer on admission (before treatment) , the 7th ,14the and 21th day during treatment ,respectively .Patients were divided into large ,middle and small infarction group ac‐cording to the infarct size determined by color Doppler .The correlation between BNP ,D‐dimer and infarct size were analysed .Re‐sults BNP levels in small ,medium and large infarction group were (165 .0 ± 26 .3) ,(237 .0 ± 39 .4) ,(413 .0 ± 61 .2)pg/mL ,respec‐tively ,and the differences were statistically significant(P<0 .05) .The D‐dimer plasma concentrations in the three groups were all higher than the normal reference level(P<0 .05) .In the course of thrombolytic therapy displayed a dynamic change process ,the level of D‐dimer increased first ,then maintained at a relatively high level ,and finally decreased and returned to the normal level . Conclusion The area of myocardial infarction has a certain correlation with the level of BNP ,and the dynamic monitoring of D‐di‐mer can be used to evaluate the effect of thrombolytic therapy .