The value of dual-energy CT iodine image and NICnod in diagnosis of thyroid cancer / 实用放射学杂志

ABSTRACT

Objective To investigate the value of dual‐energy CT iodine image morphology and iodine concentration in thyroid cancer diagnosis .Methods The patients underwent dual‐energy contrast scanning and confirmed with pathology results were en‐rolled .90 cases (60 malignant nodules and 30 benign nodules) were chosen with the CT value of internal carotid110-250 HU at ar‐terial phase and 70-110 HU at venous phase .The iodine concentration of normal thyroid and neoplasms were measured respective‐ly ,as well as the NICnod (normalized iodine concentration) .Then the data was compared among each groups .The iodine image mor‐phology was also analyzed of each neoplasms ,and sensitivity ,specificity and accuracy were calculated .Results ①In the iodine image the characteristics of thyroid cancer ,including irregular shape ,invading neighbor structure and uncompleted enhanced ring around the tumor ,have significant differences compared with normal CT image (P all0 .05) .②There were significant differences in the venous phase NICnod value from normal groups ,malignant groups and benign groups (P<0 .05) .When diagnosed as malignant tumor ,the critical NICnod was under 0 .76 ,the area under the ROC curve of AUC value were 0 .91 ,the sensitivity and specificity were 74 .61% and 75 .60% ,respectively .③The sensitivity ,specificity and accuracy of iodine image combined with the NICnod to diagnose thyroid cancer were 91 .67% ,86 .67% , 94 .44% ,respectively .Conclusion Dual‐energy CT iodine image morphology and iodine concentration have important value in thyroid cancer diagnosis .