Effect of Amantadine on Weight Gain Induced by Olanzapine / 대한정신약물학회지
Korean Journal of Psychopharmacology
;
: 23-27, 2003.
Article
in Korean
| WPRIM
| ID: wpr-48692
ABSTRACT
OBJECTIVE:
Weight gain is a commonly encountered problem associated with atypical antipsychotics, especially olanzapine. To investigate the weight reducing effect of amantadine, we conducted an prospective open label study.METHODS:
We started amantadine treatment in outpatients who had gained weight during olanzapine treatment (mean dose of 11.94 mg/day, mean weight gain of 6.33 kg). Data were collected at St. Mary's Hospital, College of Medicine, The Catholic University of Korea. The add-on treatment of amantadine was given at a mean dose of 161.9 mg/day with mean duration of administration for 110.2 day. Brief Psychiatric Rating Scale (BPRS), Extrapyramidal Symptom Scale were checked to evaluate the tolerability of amantadine.RESULTS:
Before administration of amantadine, the mean dose of olanzapine was 11.94+/-4.58 mg and mean duration of administration was 123.1+/-174.6 days. Body weight and BMI during this period was significantly increased mean 6.33+/-4.45 kg (Z=-3.839, p<0.001), 4.94+/-0.75 (Z=-3.724, p<0.001) respectively. Amantadine was administered mean dose of 161.90+/-58.96 mg for mean 110.2+/-78.7 days. Body weight and BMI was decreased mean 0.96+/-3.44 kg, 0.71+/-2.7, respectively. There was no deterioration in psychiatric symptoms, as shown in BPRS score decrement and no adverse effects were reported.CONCLUSION:
The present data suggests that amantadine does not significantly decrease weight gain experienced by some patients during olanzapine treatment and does not worse psychotic symptoms. Randomized placebo-controlled trial should be needed to confirm these findings.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Brief Psychiatric Rating Scale
/
Outpatients
/
Antipsychotic Agents
/
Body Weight
/
Weight Gain
/
Amantadine
/
Prospective Studies
/
Korea
Type of study:
Controlled clinical trial
/
Observational study
Limits:
Humans
Country/Region as subject:
Asia
Language:
Korean
Journal:
Korean Journal of Psychopharmacology
Year:
2003
Type:
Article
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