Stereoisomerism(Chirality) of Psychotropic Drugs / 대한정신약물학회지
Korean Journal of Psychopharmacology
;
: 3-10, 2003.
Article
in Korean
| WPRIM
| ID: wpr-48694
ABSTRACT
Many psychotropic drugs are marketed and prescribed as a racemate form in a mixture of the stereoisomers. A chiral center or a center of unsaturation of carbon atoms in the chemical structures creates various stereoisomers of the psychotropic drugs, including antidepressants such as fluoxetine and venlafaxine, etc. The stereochemical significances of enantiomers on the pharmacokinetics and pharmacodynamics of several psychotropic drugs and their relationships with pharmacogenetic polymorphisms were reviewed. The single enantiomer drugs will be increasing more in the market shares replacing the racemic drugs by chiral switching, which is driven by the development of the analytical and preparative resolution techniques and will be of much benefit to the treatment from low dosages, simple dose-response curve, few adverse reactions, and so on.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Psychotropic Drugs
/
Stereoisomerism
/
Carbon
/
Pharmacokinetics
/
Fluoxetine
/
Venlafaxine Hydrochloride
/
Antidepressive Agents
Language:
Korean
Journal:
Korean Journal of Psychopharmacology
Year:
2003
Type:
Article
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