TIGAR promotes proliferation and invasiveness of lung cancer cells / 国际检验医学杂志
International Journal of Laboratory Medicine
;
(12): 754-755, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-487155
ABSTRACT
Objective To study the role of P53 target gene TIGAR on proliferation ,migration and invasion of lung cancer cells . Methods siRNA was introduced to knock down TIGAR in A 549 cells .Proliferation was detected by CCK-8 .The ability of migra-tion and invasion was measured by and ,respectively .was used to evaluate the expression levels of related proteins .Results Knock-down of TIGAR reduced the proliferation rate (P< 0 .05) ,inhibited the ability of migration and invasion ,decreased expression levels of MMP-2 and MM P-9 .Conclusion TIGAR promotes proliferation ,migration and invasiveness of lung cancer cells .
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
International Journal of Laboratory Medicine
Year:
2016
Type:
Article
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