Effects of Huoxue Jiangtang Yin Combined with Metformin on Glucose and Lipid Metabolism and Fat Factors in Type 2 Diabetes Patients with Insulin Resistance / 广州中医药大学学报

ABSTRACT

Objective To investigate the effects of the decoction of Huoxue Jiangtang Yin (HJY) combined with metformin on glucose and lipid metabolism and fat factors in type 2 diabetes patients with insulin resistance ( IR). Methods A total of 84 type 2 diabetes patients with IR were randomly assigned to experiment group and control group, 42 cases in each group. Both groups were given the basic treatment of controlling diet, exercise therapy, banning from smoking and alcohol, and psychological therapy. Additionally, the control group was given metformin orally, and the experiment group was given oral use of metformin and the decoction of HJY ( mainly composed of Radix Astragalie, Rhizoma Rehmanniae, Radix Salviae Miltiorrhizae, Radix Pseudostellariae, Fructus Schisandrae, Radix Ophiopogonis, Radix Dioscoreae, Rhizoma Polygonati, Cortex Moutan, Radix et Rhizoma Rhei, Flos Carthami, and Semen Persicae). The treatment for both groups covered 20 weeks for a course of treatment. Before and after the treatment, we observed the indexes of fasting plasma glucose (FPG), 2-h postprandial plasma glucose (2hPG), glycosylated hemoglobin (HbA1c), fasting insulin ( FINS) , homeostasis model assessment of insulin resistance ( HOMA-IR) , body mass index ( BMI) , blood lipid of total cholesterol ( TC) , triglyceride ( TG) and low density lipoprotein cholesterol ( LDL-C) , interleukin 6 ( IL -6) , tumor necrosis factor alpha ( TNF-α) , and secreted frizzled related protein 5 ( SFRP5). Results After treatment, FPG, 2hPG, HbA1c, BMI, FINS, TC, TG, LDL-C, HOMA-IR, TNF-α and IL -6 levels were all decreased (P<0.05 or P<0.01), and SFRP5 level was increased (P<0.05) in both groups compared with those before treatment. The improvement of the indexes in the experiment group was superior to that in the control group ( P<0.05 or P<0.01) Conclusion HJY combined with metformin has an effect on controlling body weight, regulating the glucose and lipid metabolism, and improving IR through regulating fat factors of IL-6, TNF-α and SFRP5 in type 2 diabetes patients with IR.