Determination of the Enantiomer in Safinamide Mesilate by HPLC / 中国药师
China Pharmacist
;
(12): 582-584, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-487351
ABSTRACT
Objective:
To establish a determination method for the enantiomer in safinamide mesilate.Methods:
A Chiralpak ASH (250 mm ×4. 6 mm, 5 μm) column was used with the mobile phase of n-hexane-ethanol-diethylamine (75 ∶ 25 ∶ 0. 1). The flow rate was 1. 0 ml·min-1 . The wavelength was set at 225 nm. The column temperature was 35℃.Results:
The resolution of safinamide mesilate and the enantiomer was above 2. 0. The linear range of them was 1. 007-2 517. 500 μg·ml-1 and 0. 909-2273. 200 μg·ml-1 ,respectively(r = 0. 999 0). The average recovery of the enantionmer was 104. 9% with RSD of 2. 3% (n = 9).Conclusion:
The method is accurate and rapid, and suitable for the determination of the enantiomer in safinamide mesilate.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacist
Year:
2016
Type:
Article
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