The relationship between progressive liver fibrosis and diabetic neuropathy / 天津医药

ABSTRACT

Objective To study the relationship between advanced liver fibrosis and peripheral neuropathy in patients with type 2 diabetes mellitus (DPN). Methods A total of 173 patients (89 men and 84 women) with type 2 diabetes who hos?pitalized in Tianjin Third Central Hospital within nearly three years (2013.02-2015.02) were divided into three groups ac?cording to non-alcoholic fatty liver disease (NAFLD) fibrosis scoregroup A (NFS≤-1.455), group B (-1.455prevalence of DPN, sensory nerve conduction abnormalities (SNCA), motor nerve conduction abnormalities (MNCA) were compared, and the influencing factors were analysis between three groups. DPN, MNCA and SN?CA were ascertained by electroneurogram, and the severity of liver fibrosis was ascertained by NAFLD fibrosis score. Re?sults The prevalence rates of DPN, SNCA and MNCA were 69.4%, 78.9%, 86.2%, 65.3%, 73.7%, 86.2%, 38.8%, 49.5%and 65.5%in group A, group B and group C. There was no significant statistical difference between the three groups. Logistic regression analysis indicated that high NFS was an independent risk factor of DPN, SNCA and MNCA. Conclusion NAFLD fibrosis has a relationship with the prevalence rate of DPN, which is an independent risk factor of DPN, SNCA and MNCA in patients with T2DM.